Metabolomics and metabolism

Mass spectroscopy based metabolomics

This metabolomics offers quantitative analysis with a high selectivity and sensitivity with a  potential to identify the metabolites. Different ionization techniques are obtained to maximize the number of detected metabolites. Both (GC)-MS and (LC)-MS are superior for targeted analyses. In in-vivo studies , desorption electrospray ionization (DESI) may be a useful way to analyze tissue samples during surgery, MS is not used for in vivo metabolomics studies. The main chromatography techniques that are specifically coupled with MS are HPLC, gas chromatography, and capillary electrophoresis (CE). For example, investigations detailing a number of diseases including breast cancer, colorectal cancer, prostate cancer, esophageal and gastric cancer, cardiovascular diseases, kidney diseases , inborn errors of metabolism.