Metabolomics and metabolism

Cancer metabolism

The regulation of metabolic reactions in the cancer cell or the surrounding  stroma  generate intermediates that are at the key of cancer pathogenesis, progression, and therapy resistance. Tumours exhibit a wide range of  varieties in molecular alterations that merge in metabolic reprogramming. Warburg’s work focused on the metabolic reprogramming of cancer cells, which is now consider as one of the hallmarks of cancer as put forward by Douglas Hanahan and Robert Weinberg in Hallmarks of Cancer. The metabolic profile observed in cancer cells often shows increased consumption of glucose and glutamine, increased glycolysis, alterations in the use of metabolic enzyme isoforms, and increased secretion of lactate. The hallmarks of cancer are Deregulated cellular energetics, sustaining proliferative signaling, Evading growth suppressors, Avoiding immune destruction, Enabling replicative immortality, Tumour promoting inflammation, Resisting cell death.